Gerard Karsenty


United States
Also Known As
M.D., Ph.D

Gerard Karsenty M.D., Ph.D., is the Paul A. Marks M.D., Professor and Chair of the Department of Genetics and Development at Columbia University Medical center, New York City. In the last 20 years, his laboratory has studied every aspect of skeletal biology ranging from development to physiology. His laboratory deciphered the molecular bases of osteoblast-specific gene expression, a work that culminated in his identification of Runx2 as the master gene of osteoblast differentiation. This was followed by the identification of an entire cascade of transcription factors regulating osteoblast differentiation and of Gcm2 as the master gene of parathyroid gland development. In approaching bone physiology Karsenty proposed that there is a coordinated control endocrine in nature, of bone mass, energy metabolism and fertility. The Karsenty lab has verified in the mouse and whenever possible in humans all tenets of this hypothesis. One of them is that bone should be an endocrine organ regulating energy metabolism and reproduction. This led to the identification of osteocalcin as a bone-derived hormone needed for insulin secretion, glucose homeostasis, testosterone secretion by Leydig cells of the testes and male fertility, brain development cognition and adaptation to exercise. Currently his work focuses through the definition of all functions of osteocalcin in understanding why would bone be an endocrine organ. Honors & Awards 2017: Elected Associate Member of EMBO 2017: The AACE Frontiers in Science Award 2016: Steven's Triennial Prize for Excellence in Original Medical Research 2016: Roy E. Greep Award for Excellence in Basic Science, the Endocrine Society 2014: Member National Academy of Medicine 2012: Hoffenberg International Medal British Endocrine Society 2011: ASBMR William F. Neuman Award 2011: Herbert Fleisch Achievement Award in Basic Science, IOF 2011: Senior Scholar in Aging Ellison Foundation 2010: Jacobaeus Prize NovoNordisk Foundation, Denmark 2010: Member, College of CSR Reviewers, NIH 2010: Richard Lounsbery Award, National Academy of Science (USA), Academie des Sciences (France) 2008: Lee C. Howley Prize for Arthritis Research, Arthritis Foundation 2007: Schaefer Award, Columbia University Medical Center 2007: Drieu-Cholet Award, The French National Academy of Medicine 2006: Edith and Peter O’Donnell Award, The Academy of Medicine, Engineering and Science of Texas 2002: Member of The Association of American Physicians 2001: Louis V. Avioli Founders Award of the ASBMR 2001: D. Harold Copp Award of the IBMS 2000: Michael E. De Bakey Excellence in Science Award 1997: Research Award of the Austrian Bone and Mineral Research Society 1996: International Bone and Calcium Institute Young Scientist Award 1985: French Endocrine Society Award for Young Scientists Research Genetics to understand Development, Physiology and Pathogenesis of all diseases Selected Publications 1: Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007 130(3):456-69. 2: Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G. Endocrine regulation of male fertility by the skeleton. Cell. 2011 144(5): 796-809. 3: Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty, G. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013 155(1): 228-41. 4: Wei J, Shimazu J, Makinistoglu M, Maurizi A, Kajimura D, Zong H, Takarada T, Iezaki T, Pessin JE, Hinoi E, and Karsenty G. Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation. Cell. 2015 161(7): 1576-91. 5: Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galan-Diez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I and Karsenty G. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise. Cell Metab. 2016 23(6):1078-92. 6: Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Yadav VK, Rahmouni K, Gao XB and Karsenty G. Mediation of the acute stress response by the skeleton. Cell Metab. 2019 30(5): 890-902

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